Improving signal-to-noise ratio by maximal convolution of longitudinal and transverse magnetization components in MRI: application to the breast cancer detection.

PURPOSE: The extraction of information from images provided by medical imaging systems may be employed to obtain the specific objectives in the various fields. The quantity of signal to noise ratio (SNR) plays a crucial role in displaying the image details. The higher the SNR value, the more the information is available. METHODS: In this study, a new function has been formulated using the appropriate suggestions on convolutional combination of the longitudinal and transverse magnetization components related to the relaxation times of T1 and T2 in MRI, where by introducing the distinct index on the maximum value of this function, the new maps are constructed toward the best SNR. Proposed functions were analytically simulated using Matlab software and evaluated with respect to various relaxation times. This proposed method can be applied to any medical images. For instance, the T1- and T2-weighted images of the breast indicated in the reference [35] were selected for modelling and construction of the full width at x maximum (FWxM) map at the different values of x-parameter from 0.01 to 0.955 at 0.035 and 0.015 intervals. The range of x-parameter is between zero and one. To determine the maximum value of the derived SNR, these intervals have been first chosen arbitrarily. However, the smaller this interval, the more precise the value of the x-parameter at which the signal to noise is maximum. RESULTS: The results showed that at an index value of x = 0.325, the new map of FWxM (0.325) will be constructed with a maximum derived SNR of 22.7 compared to the SNR values of T1- and T2-maps by 14.53 and 17.47, respectively. CONCLUSION: By convolving two orthogonal magnetization vectors, the qualified images with higher new SNR were created, which included the image with the best SNR. In other words, to optimize the adoption of MRI technique and enable the possibility of wider use, an optimal and cost-effective examination has been suggested. Our proposal aims to shorten the MRI examination to further reduce interpretation times while maintaining primary sensitivity. SIGNIFICANCE: Our findings may help to quantitatively identify the primary sources of each type of solid and sequential cancer.

Tumor segmentation via enhanced area growth algorithm for lung CT images.

BACKGROUND: Since lung tumors are in dynamic conditions, the study of tumor growth and its changes is of great importance in primary diagnosis. METHODS: Enhanced area growth (EAG) algorithm is introduced to segment the lung tumor in 2D and 3D modes on 60 patients CT images from four different databases by MATLAB software. The contrast augmentation, color intensity and maximum primary tumor radius determination, thresholding, start and neighbor points' designation in an array, and then modifying the points in the braid on average are the early steps of the proposed algorithm. To determine the new tumor boundaries, the maximum distance from the color-intensity center point of the primary tumor to the modified points is appointed via considering a larger target region and new threshold. The tumor center is divided into different subsections and then all previous stages are repeated from new designated points to define diverse boundaries for the tumor. An interpolation between these boundaries creates a new tumor boundary. The intersections with the tumor boundaries are firmed for edge correction phase, after drawing diverse lines from the tumor center at relevant angles. Each of the new regions is annexed to the core region to achieve a segmented tumor surface by meeting certain conditions. RESULTS: The multipoint-growth-starting-point grouping fashioned a desired consequence in the precise delineation of the tumor. The proposed algorithm enhanced tumor identification by more than 16% with a reasonable accuracy acceptance rate. At the same time, it largely assurances the independence of the last outcome from the starting point. By significance difference of p < 0.05, the dice coefficients were 0.80 ± 0.02 and 0.92 ± 0.03, respectively, for primary and enhanced algorithms. Lung area determination alongside automatic thresholding and also starting from several points along with edge improvement may reduce human errors in radiologists' interpretation of tumor areas and selection of the algorithm's starting point. CONCLUSIONS: The proposed algorithm enhanced tumor detection by more than 18% with a sufficient acceptance ratio of accuracy. Since the enhanced algorithm is independent of matrix size and image thickness, it is very likely that it can be easily applied to other contiguous tumor images. TRIAL REGISTRATION: PAZHOUHAN, PAZHOUHAN98000032. Registered 4 January 2021, http://pazhouhan.gerums.ac.ir/webreclist/view.action?webreclist_code=19300.

Evaluation of gamma and electron radiations impact on vitamins for onion preservation.

Food irradiation is a process in which food and other consumer products are exposed to gamma rays, X-rays or electron beams after extraction. This method is particularly important in order to reduce infectious agents and to extend the shelf life of the product. The target radiation is done with different devices, so self-sufficient radiation and panoramic radiation -including product and source overlap, planar and categorical radiation- is the major characteristics. Besides, a high performance liquid chromatography device (10% methanol, 70%-80% distilled water and 10% ethanol) is utilized to measure the chemical substance of pyridoxine (vitamin B3), thiamine (vitamin B6) and vitamin C of Vidalia or sweet onions. In our research, gamma-cell 220 and Rhodorton electron facilities were utilized to irradiate the onion crop. This project focuses on increasing the shelf life of agricultural products, especially onions, using energy of 1.25 MeV for both gamma irradiation and electron beam, and measuring the amount of vitamins B3, B6 and C, which are the nutrients of this product. The prepared onion samples were exposed under electron and gamma irradiations by two doses of 200 and 500 Gy at 25 °C. Then, a liquid chromatography device was utilized to measure the vitamins. The results showed that the onions were not damaged by 200 Gy doses and their nutritional properties were preserved, which means that not only can vitamins with this dose be retained without any spoilage for 30 days, but also eliminate pathogenic microorganisms. The process indicated that using 200 Gy radiations does not endanger the health of food and consumers.

Introducing a novel coefficient on mixed-nanoparticles material: relationship between the theoretical and experimental densities.

Nanoparticles (NPs) indicating a unique potential in bioradiation and nuclear reactor shielding are employed in many fields due to their particular specifications leading improving the mechanical properties as well as pore structure of the concrete-shield. The aim was to introduce a novel coefficient ( ξ ), namely the experimental to theoretical density ratio for mixed-NPs material at various nanoparticles percent concentrations ( ω n a n o ) based on pure mathematical aspects along with the some suitable physical purposes by Monte Carlo method. The change in the mixture density to the change in ω n a n o is always proportional to the ω n a n o value. The density will become maximum at the ω n a n o ∗ in which the physical, morphological and chemical features of NPs along with the amounts of voids in the material have a key role over estimating porosity percentage. The NPs' separation probability as born-cascaded-pairs towards very small radii may be formulated as ξ - ξ - 1 + ω n a n o ∗ + k ' ' | ω n a n o - ω n a n o ∗ | = k ' where k ' and k ' ' are constant values. In conclusion, the theoretical results may be experimentally used in future work for different applications such as designing shield at a nuclear facility.

Estimation of microvascular capillary physical parameters using MRI assuming a pseudo liquid drop as model of fluid exchange on the cellular level.

AIM: One of the most important microvasculatures' geometrical variables is number of pores per capillary length that can be evaluated using MRI. The transportation of blood from inner to outer parts of the capillary is studied by the pores and the relationship among capillary wall thickness, size and the number of pores is examined. BACKGROUND: Characterization of capillary space may obtain much valuable information on the performance of tissues as well as the angiogenesis. METHODS: To estimate the number of pores, a new pseudo-liquid drop model along with appropriate quantitative physiological purposes has been investigated toward indicating a package of data on the capillary space. This model has utilized the MRI perfusion, diffusion and relaxivity parameters such as cerebral blood volume (CBV), apparent diffusion coefficient (ADC), ΔR 2 and Δ R 2 * values. To verify the model, a special protocol was designed and tested on various regions of eight male Wistar rats. RESULTS: The maximum number of pores per capillary length in the various conditions such as recovery, core, normal-recovery, and normal-core were found to be 183 ± 146, 176 ± 160, 275 ± 166, and 283 ± 143, respectively. This ratio in the normal regions was more than that of the damaged ones. The number of pores increased with increasing mean radius of the capillary and decreasing the thickness of the wall in the capillary space. CONCLUSION: Determination of the number of capillary pore may most likely help to evaluate angiogenesis in the tissues and treatment planning of abnormal ones.

Determination of Gamma Camera's Calibration Factors for Quantitation of Diagnostic Radionuclides in Simultaneous Scattering and Attenuation Correction.

OBJECTIVE: The characterization of cancerous tissue and bone metastasis can be distinguished by accurate assessment of accumulated uptake and activity from different radioisotopes. The various parameters and phenomena such as calibration factor, Compton scattering, attenuation and penetration intrinsicallyinfluence calibration equation, and the qualification of images as well. METHODS: The camera calibration factor (CF) translates reconstructed count map into absolute activity map, which is determined by both planar and tomographic scans using different phantom geometries. In this study, the CF for radionuclides of Tc-99m and Sm-153 in soft tissue and bone was simulated by the Monte Carlo method, and experimental results were obtained in equivalent tissue and bone phantoms. It may be employed for the simultaneous correction of the scattering and attenuation rays interacted with the camera, leading to corrected counts. Also, the target depth (d) may be estimated by a combination of scattering and photoelectric functions, which we have published before. RESULTS: The calibrated equations for soft tissue phantom for the radionuclides were obtained by RTc = - 10d+ 300 and RSm = -8d + 100, and the relative errors between the simulated and experimental results were 4.5% and 3.1%, respectively. The equations for bone phantom were RTc = -30d + 300 and RSm = - 10d + 100, and the relative errors were 5.4% and 5.6%. The R and d are in terms of cpm/mCi and cm. Besides, the collimators' impact was evaluated on the camera response, and the relevant equations were obtained by the Monte Carlo method. The calibrated equations as a function of various radiation angles on the center of camera's cells without using collimator indicated that both sources have the same quadratic coefficient by -2E-08 and same vertical width from the origin by 8E-05. CONCLUSION: The presented procedure may help determine the absorbed dose in the target and likewise optimize treatment planning.

Spectroscopy and Optimizing Semiconductor Detector Data Under X and γ Photons Using Image Processing Technique.

BACKGROUND: Spectroscopy is the study of the absorption and emission of light or other radiation by material. It is used to measure intensity of radiation by a function of wavelength. METHODS: The spectra of semiconductor detector cadmium tungstate from water, iron, lead, aluminum, and soft tissue targets were experimentally obtained through incident 1E-3 GeV X-ray and 60Co Î³-ray and then optimized. The amounts of transmitting radiation attenuation were calculated in 0.2-2 cm thicknesses of the materials using reduction coefficient in theory. Data obtained from FLUKA's simulations were then compared with theoretical values by dividing per theoretical parameter, and mean values were obtained for the attenuation coefficients. Finally, by using the MATLAB software, these corrected coefficients were applied to the simulated data, and the spectra were replotted to optimize the detected values. RESULTS: These obtained parameters increased while the material density increased, except for water and soft tissue materials under γ-ray of 60Co. The multiple Compton scattering inside the low-density material affected the γ-photon deviation to reach the crystal. Also, iron had the lowest values of mass attenuation coefficient for both incident radiations, causing a great corrected coefficient and then a greater count in redrawing. DISCUSSION: Although the lead material had the greatest density and X-attenuation coefficient, it revealed large amounts for both corrected coefficients, X and γ rays, of 100.90848 and 1.90900, respectively. In count estimation, results showed that the simulated spectra after optimization are more similar to practical spectra. CONCLUSION: The policy on reducing radiation damage from ionizing particles necessitates evaluation of various material behaviors to determine which one will be instrumental for imaging or radiotherapy concerns.

Accelerator driven neutron source design via beryllium target and 208Pb moderator for boron neutron capture therapy in alternative treatment strategy by Monte Carlo method.

AIMS: The reactor has increased its area of application into medicine especially boron neutron capture therapy (BNCT); however, accelerator-driven neutron sources can be used for therapy purposes. The present study aimed to discuss an alternative method in BNCT functions by a small cyclotron with low current protons based on Karaj cyclotron in Iran. MATERIALS AND METHODS: An epithermal neutron spectrum generator was simulated with 30 MeV proton energy for BNCT purposes. A low current of 300 µA of the proton beam in spallation target concept via 9Be target was accomplished to model neutron spectrum using 208Pb moderator around the target. The graphite reflector and dual layer collimator were planned to prevent and collimate the neutrons produced from proton interactions. Neutron yield per proton, energy distribution, flux, and dose components in the simulated head phantom were estimated by MCNPX code. RESULTS: The neutron beam quality was investigated by diverse filters thicknesses. The maximum epithermal flux transpired using Fluental, Fe, Li, and Bi filters with thicknesses of 7.4, 3, 0.5, and 4 cm, respectively; as well as the epithermal to thermal neutron flux ratio was 161. Results demonstrated that the induced neutrons from a low energy and low current proton may be effective in tumor therapy using 208Pb moderator with average lethargy and also graphite reflector with low absorption cross section to keep the generated neutrons. CONCLUSIONS: Combination of spallation-based BNCT and proton therapy can be especially effective, if a high beam intensity cyclotron becomes available.

Gold nanoparticles production using reactor and cyclotron based methods in assessment of (196,198)Au production yields by (197)Au neutron absorption for therapeutic purposes.

Medical nano-gold radioisotopes is produced regularly using high-flux nuclear reactors, and an accelerator-driven neutron activator can turn out higher yield of (197)Au(n,γ)(196,198)Au reactions. Here, nano-gold production via radiative/neutron capture was investigated using irradiated Tehran Research Reactor flux and also simulated proton beam of Karaj cyclotron in Iran. (197)Au nano-solution, including 20nm shaped spherical gold and water, was irradiated under Tehran reactor flux at 2.5E+13n/cm(2)/s for (196,198)Au activity and production yield estimations. Meanwhile, the yield was examined using 30MeV proton beam of Karaj cyclotron via simulated new neutron activator containing beryllium target, bismuth moderator around the target, and also PbF2 reflector enclosed the moderator region. Transmutation in (197)Au nano-solution samples were explored at 15 and 25cm distances from the target. The neutron flux behavior inside the water and bismuth moderators was investigated for nano-gold particles transmutation. The transport of fast neutrons inside bismuth material as heavy nuclei with a lesser lethargy can be contributed in enhanced nano-gold transmutation with long duration time than the water moderator in reactor-based method. Cyclotron-driven production of ßeta-emitting radioisotopes for brachytherapy applications can complete the nano-gold production technology as a safer approach as compared to the reactor-based method.

Estimation of the Number of Compartments Associated With the Apparent Diffusion Coefficient in MRI: The Theoretical and Experimental Investigations.

OBJECTIVE: The goal of the present study was to estimate the number of compartments and the mean apparent diffusion coefficient (ADC) value with the use of the DWI signal curve. MATERIALS AND METHODS: A useful new mathematic model that includes internal correlation among subcompartments with a distinct number of compartments was proposed. The DWI signal was simulated to estimate the approximate association between the number of subcompartments and the molecular density, with density corresponding to the ratio of the ADC values of the compartments, as determined using the Monte Carlo method. RESULTS: Various factors, such as energy depletion, temperature, intracellular water accumulation, changes in the tortuosity of the extracellular diffusion paths, and changes in cell membrane permeability, have all been implicated as factors contributing to changes in the ADC of water (ADCw); therefore, one may consider them as pseudocompartments in the new model proposed in this study. The lower the coefficient is, the lower the contribution of the compartment to the net signal will be. The results of the simulation indicate that when the number of compartments increases, the signal will become significantly lower, because the gradient factor (i.e., the b value) will increase. In other words, the signal curve is approximately linear at all b values when the number of compartments in which the tissues have been severely damaged is low; however, when the number of compartments is high, the curve will become constant at high b values, and the perfusion parameters will prevail on the diffusion parameters at low b values. Therefore, normal tissues will be investigated when the number of compartments and the ADC values are high and the b values are low, whereas damaged tissues will be evaluated when the number of compartments and the ADC values are low and the b values are high. CONCLUSION: The present study investigates damaged tissues at high b values for which the effect of eddy currents will also be compensated. These b values will probably be used in functional MRI.

Exploration of Adiabatic Resonance Crossing Through Neutron Activator Design for Thermal and Epithermal Neutron Formation in (99)Mo Production and BNCT Applications.

A feasibility study was performed to design thermal and epithermal neutron sources for radioisotope production and boron neutron capture therapy (BNCT) by moderating fast neutrons. The neutrons were emitted from the reaction between (9)Be, (181)Ta, and (184)W targets and 30 MeV protons accelerated by a small cyclotron at 300 µA. In this study, the adiabatic resonance crossing (ARC) method was investigated by means of (207)Pb and (208)Pb moderators, graphite reflector, and boron absorber around the moderator region. Thermal/epithermal flux, energy, and cross section of accumulated neutrons in the activator were examined through diverse thicknesses of the specified regions. Simulation results revealed that the (181)Ta target had the highest neutron yield, and also tungsten was found to have the highest values in both surface and volumetric flux ratio. Transmutation in the (98)Mo sample through radiative capture was investigated for the natural lead moderator. When the sample radial distance from the target was increased inside the graphite region, the production yield had the greatest value of activity. The potential of the ARC method is a replacement or complements the current reactor-based supply sources of BNCT purposes.

Evaluation of a Proposed Biodegradable 188Re Source for Brachytherapy Application: A Review of Dosimetric Parameters.

This study aimed to evaluate dosimetric characteristics based on Monte Carlo (MC) simulations for a proposed beta emitter bioglass 188Re seed for internal radiotherapy applications. The bioactive glass seed has been developed using the sol-gel technique. The simulations were performed for the seed using MC radiation transport code to investigate the dosimetric factors recommended by the AAPM Task Group 60 (TG-60). Dose distributions due to the beta and photon radiation were predicted at different radial distances surrounding the source. The dose rate in water at the reference point was calculated to be 7.43 ±â€Š0.5 cGy/h/µCi. The dosimetric factors consisting of the reference point dose rate, D(r0,θ0), the radial dose function, g(r), the 2-dimensional anisotropy function, F(r,θ), the 1-dimensional anisotropy function, φan(r), and the R90 quantity were estimated and compared with several available beta-emitting sources. The element 188Re incorporated in bioactive glasses produced by the sol-gel technique provides a suitable solution for producing new materials for seed implants applied to brachytherapy applications in prostate and liver cancers treatment. Dose distribution of 188Re seed was greater isotropic than other commercially attainable encapsulated seeds, since it has no end weld to attenuate radiation. The beta radiation-emitting 188Re source provides high doses of local radiation to the tumor tissue and the short range of the beta particles limit damage to the adjacent normal tissue.

Evaluation of Compton attenuation and photoelectric absorption coefficients by convolution of scattering and primary functions and counts ratio on energy spectra.

PURPOSE: Estimation of Compton attenuation and the photoelectric absorption coefficients were explored at various depths. METHODS: A new method was proposed for estimating the depth based on the convolution of two exponential functions, namely convolution of scattering and primary functions (CSPF), which the convolved result will conform to the photopeak region of energy spectrum with the variable energy-window widths (EWWs) and a theory on the scattering cross-section. The triple energy-windows (TEW) and extended triple energy-windows scatter correction (ETEW) methods were used to estimate the scattered and primary photons according to the energy spectra at various depths due to a better performance than the other methods in nuclear medicine. For this purpose, the energy spectra were employed, and a distinct phantom along with a technetium-99 m source was simulated by Monte Carlo method. RESULTS: The simulated results indicate that the EWW, used to calculate the scattered and primary counts in terms of the integral operators on the functions, was proportional to the depth as an exponential function. The depth will be calculated by the combination of either TEW or ETEW and proposed method resulting in the distinct energy-window. The EWWs for primary photons were in good agreement with those of scattered photons at the same as depths. The average errors between these windows for both methods TEW, and ETEW were 7.25% and 6.03% at different depths, respectively. The EWW value for functions of scattered and primary photons was reduced by increasing the depth in the CSPF method. CONCLUSIONS: This coefficient may be an index for the scattering cross-section.

Modulation transfer function assessment in parallel beam and fan beam collimators with square and cylindrical holes.

OBJECTIVE: This study investigates modulation transfer function (MTF) in parallel beam (PB) and fan beam (FB) collimators using the Monte Carlo method with full width at half maximum (FWHM), square and circular-shaped holes, and scatter and penetration (S + P) components. METHODS: A regulation similar to the lead-to-air ratio was used for both collimators to estimate output data. The hole pattern was designed to compare FB by PB parameters. The radioactive source in air and in a water phantom placed in front of the collimators was simulated using MCNP5 code. RESULTS: The test results indicated that the square holes in PB (PBs) had better FWHM than did the cylindrical (PBc) holes. In contrast, the cylindrical holes in the FB (FBc) had better FWHM than the square holes. In general, the resolution of FBc was better than that of the PBc in air and scatter mediums. The S + P decreased for all collimators as the distance from the source to the collimator surface (z) increased. The FBc had a lower S + P than FBs, but PBc had a higher S + P than PBs. Of the FB and PB collimators with the identical hole shapes, PBs had a smaller S + P than FBs, and FBc had a smaller S + P than PBc. The MTF value for the FB was greater than for the PB and had increased spatial frequency; the FBc had higher MTF than the FBs and PB collimators. CONCLUSIONS: Estimating the FB using PB parameters and diverse hole shapes may be useful in collimator design to improve the resolution and efficiency of SPECT images.

Evaluation of collimators' response: round and hexagonal holes in parallel and fan beam.

With regard to the different requirements, various collimators are widely employed within nuclear medicine systems in order to evaluate the metabolism of organs as well as improve the contrast of images and better diagnosis. In this study, Fan Beam (FB) and Parallel Beam (PB) collimators in the shapes of round and hexagonal holes have been investigated and compared based on the Geometric Efficiency (G), Geometric Resolution (R(c)), Total Resolution (R(t)), FWHM and Scatter and Penetration (S + P) components using the Monte Carlo simulation. Calculations demonstrated that the G was improved with the increase in the distance between point source and collimator face (z). In contrast, the G was reduced with an increase in the angle of slant hole. In the FB collimator, the R(c) and R(t) were increased when the increase in the hole angle and/or the distance. The simulated results indicated in both collimators with the increase in z, a) the FWHM was increased as well as the peak of the PSF curve was decreased, and b) the S + P amounts decreased, but in the distinct z, the FWHM of the FB collimator is better than that of the PB collimator. It is shown that the results were in agreement with the ADAC company data. Also, Benchmark for measuring ADAC company demonstrated the calculated and simulated amounts of the R(c) and R(t) with round and hexagonal holes shapes had maximum and minimum average relative differences equal to -7.6% for PB and 1% for FB, respectively.

Estimation of fan beam and parallel beam parameters in a wire mesh design.

UNLABELLED: Special collimators used in imaging systems play an important part in obtaining qualified images to improve diagnosis in medicine. METHODS: The primary aim of this study was to compare resolution between fan beam and parallel beam collimators using Monte Carlo simulation in the shape of cubic holes. Also, parameters such as geometric efficiency, geometric resolution, scatter, penetration, and full width at half maximum were studied to compare their special characteristics. RESULTS: The simulation results demonstrated that the geometry efficiency of a fan beam collimator increased as the angle of the slant hole increased, and the geometric resolution decreased as the angle of the slant hole increased, at a distinct distance from a monoenergetic source of γ-rays. In contrast, at a distinct angle, geometric resolution increased as the distance between the source and the collimator surface increased. For both collimators, scatter and penetration decreased as the distance increased. These results were in agreement with ADAC company data. Finally, fan beam collimators were found to have better resolution than parallel beam collimators with a cubic hole shape in a wire mesh design. CONCLUSION: Estimation of the fan beam by parallel beam parameters as cubic holes can be suitable in collimator design to improve resolution and efficiency.